A group of scientists from Haifa (Israel) has used skin stem cells from two patients suffering from heart failure and converted them into healthy heart muscle cells - cardiomyocytes - to later attach them to a sample of the damaged heart tissue and verify that , after a period of between 24 and 48 hours, the tissue regenerated.

To complete the study, the researchers implanted that tissue in the heart of healthy laboratory mice, and observed that the transplanted tissue established connections with the cells of cardiac tissue of animals.

That the cells are from the same patient that is going to perform the transplant could prevent your immune system reject the implanted tissue

Although stem cells from healthy young individuals had already been used to perform similar experiments, the novelty of this research -which has been published in the European Heart Journal- is that in this case the reprogrammed cells come from the patients themselves, They had previously suffered heart failure, and were 51 and 61 years old, respectively.

The fact that the cells are from the same patient to whom the transplant is to be performed is an important advantage because it could prevent the immune system of the patient from rejecting the implanted tissue. However, and as the authors of the work have warned, additional studies are still necessary to verify the behavior of the new cells when they are transplanted to the heart of patients, since at the moment they have only been tested in mice.

Stem Cell Advances in Heart Disease: Generating Muscle within an Existing Heart | Deepak Srivastava (November 2019).