An experimental therapy successfully tested in rats has allowed to reconstruct the penis and restore the erectile function of the animals by adding stem cells from their adipose tissue to a graft Traditionally composed of submucosa of the small intestine of pigs, with better results than those obtained in another group of rodents that were implanted with a conventional graft, which lacked stem cells. Two months after the intervention, the authors of the research found that in the rats treated with stem cells the circumference of the penis was greater and the tissues had been effectively restored, which favored blood circulation and the presence of nitric oxide in the organ, in addition to improving its capacity for contraction, all this is necessary to maintain the erection.

If this procedure works in humans it could represent a great advance in the treatment of Peyronie's disease, a disorder that originates due to the formation of a fibrous tissue under the skin of the penis, which results in the loss of elasticity of the male sexual organ and the contraction of the tunica albuginea, which causes the limb to shorten and curve , causing erectile dysfunction to many of the patients.

Two months after the intervention, in the rats treated with stem cells from their adipose tissue, the circumference of the penis was greater and the tissues had been effectively restored.

To correct the deformity, which affects between three and ten percent of the male population, and is more frequent after the age of 40, it is necessary to perform a surgical intervention, which depends on the degree of curvature that the organ presents. Thus, the longest side is shortened if the curvature is less than 45 degrees; On the contrary, if the curvature exceeds 45 degrees, the usual procedure is to implant a graft to lengthen the shorter side. In this surgery, grafts are used, formed by tissues extracted from the patient (autologous), or from animals such as pigs. However, according to specialists, it is better to avoid the operation when possible because the results usually do not meet the patient's expectations.

The research, carried out by scientists from the Department of Urology and Pharmacology of the Center for Health Sciences of the Tulane University of New Orleans, in the United States, has shown that by including in the grafts stem cells obtained from fat, the implants have a better behavior, fibrosis of the tissues is inhibited and the formation of new blood vessels is favored, the complications associated with the intervention are reduced, and the reconstruction improves significantly. It remains to be seen if these good results could also be achieved with patients.

Mayo Clinic Men’s Health Moment: Penile implant abridged operative video (November 2019).