A problem that scientists find when developing a vaccine capable of fighting all the strains of the virus of flu is that this virus is characterized by mutating easily and giving rise to new strains of the disease invulnerable to prophylactic treatment that are transmitted quickly.

To fight the virus effectively it is necessary to attack its internal structures that, unlike the external ones, hardly suffer modifications and these occur very slowly. In the United Kingdom, a group of scientists from the universities of Southampton and Oxford, with the collaboration of the company Retroscreen Virology, have discovered some peptides present in these internal structures of the virus that practically do not change, so that a medicine Acting against them would protect against all possible variants of the flu, from seasonal flu to more dangerous strains such as avian flu.

A vaccine that acts against peptides present in the internal structures of the influenza virus, which practically do not change, could protect against all possible variants of the disease

The researchers conducted a study in which isolated 41 people who were previously healthy and inoculated several strains of influenza virus, then take blood samples and observe how they defended their immune system infection. They then checked that the T cells, which are part of the body's immune system, were fighting the peptides discovered in the internal structures of the influenza virus, and that the more T cells a better individual had, the more defensive was their response to the disease.

The authors of the study, which has been published in Nature Medicine, conclude that to achieve an effective immunotherapy against influenza, efforts should be focused on getting a vaccine capable of increasing the level of T cells in the body because the peptides that fight these cells are common to the different strains of influenza and, of this In this way, universal protection would be achieved.

Researchers Work on One Flu Shot to Cover All Strains (November 2019).