The Center for Biomedical Research in Network-Physiopathology of Obesity and Nutrition (CIBERobn) is committed to finding a natural substance that regulates appetite. After performing various experiments on male Wistar rats under fasting conditions, the main candidate is the oleylethanolamide (OEA). This substance could act through peripheral sensors to activate the brain mechanisms that regulate appetite and satiety, giving rise to new treatments to combat obesity and other eating disorders.
Apparently, this natural component, which is produced in the small intestine and derived from oleic acids, exerts a key role in the cerebral mechanisms that regulate the intake and caloric expenditure. The advantage offered by its possible pharmacological use is that its appetite suppressant effect is peripheral, unlike the direct activation of certain cerebral pathways of most of the hunger-inhibiting drugs that exist today.
It is the peripheral component of the AEO activity that is especially attractive in terms of therapeutic approaches to combat eating disorders and obesity
"It is the peripheral component of the OAS activity that is especially attractive in terms of therapeutic approaches to combat eating disorders and obesity, since the lack of central effects of this new type of signals could lead to safe and free treatment. of the adverse effects on the nervous system that some of the medicines that today are used as appetite suppressants have ", said the head of the CIBERobn group.
It should be remembered that this type of drugs, which are absorbed in the digestive system immediately and alter the central nervous system, can cause dependence due to its psychotropic components; in addition to other fatal consequences such as arrhythmias, hypertension crisis or cerebrovascular accidents.
It also reinforces memory
On the other hand, the qualities of oleylethanolamide do not seem to stay there, as according to a recent study by the University of California in Irvine (USA) also plays a key role in the long-term fixation of memories. That is to say, it produces the consolidation of memory or the process by which superficial memories in the short term become long-term memories with meaning.
In this case, it was found that administering OEA to rodents increased memory retention by acting as a "molecular glue," helping mammals remember where and when they had eaten a meal. Thus, the relationship between OAS and long-term memory fixation could also open windows to the fight against neurodegenerative diseases, such as Alzheimer's or Parkinson's.
Source: 'Neuropharmacology' / EP